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Papke, R. L., M. Bencherif, and P. Lippiello. An evaluation of neuronal nicotinic acetylcholine receptor activation by quaternary nitrogen compounds indicates that choline is selective for the alpha 7 subtype. Neuroscience Letters 213:201-204 (1996).
- Francis, M. M., and R. L. Papke. Muscle-type Nicotinic Acetylcholine Receptor Delta Subunit Determines Sensitivity to Noncompetitive Inhibitors while Gamma Subunit Regulates Divalent Permeability. Neuropharmacology 35(11):1547-1556 (1996).
- Papke, R. L., J. S. Thinschmidt, B. A. Moulton, E. M. Meyer, and A. Poirier. Activation and inhibition of rat neuronal nicotinic receptors by ABT-418. British Journal of Pharmacology 120:429-438 (1997).
- Meyer, E. M., E. T. Tay, R. L. Papke, C. Meyers, G. Huang, and C. M. de Fiebre. Effects of 3-[2,4-dimethoxybenzylidene]anabaseine (DMXB) on rat nicotinic receptors and memory-related behaviors. Brain Research 768:49-56 (1997).
- Kem, W. R., V. M. Mahnir, R. L. Papke, and C. J. Lingle. Anabaseine is a potent agonist upon muscle and neuronal alpha-bungarotoxin sensitive nicotinic receptors. Journal of Pharmacology and experimental Therapeutics 283:979-992 (1997).
- Francis, M. M., K. I. Choi, B. A. Horenstein, and R. L. Papke. Sensitivity to voltage-independent inhibition determined by pore-lining region of ACh receptor. Biophysical Journal 74(5):2306-2317 (1998).
- Meyer, E. M., E. T. Tay, J. A. Zoltewicz, R. L. Papke, C. Meyers, M. King, and C. M. d. Fiebre. Neuroprotective and memory-related actions of novel alpha 7 nicotinic agents with different mixed agonist/antagonist properties. Journal of Pharmacology and Experimental Therapeutics 284:1026-1032 (1998).
- Kabakov, A. Y., N. B. Karkanias, R. H. Lenox, and R. L. Papke. Synapse-specific accumulation of lithium in intracellular microdomains: a model for uncoupling coincidence detection in the brain. 28(4):271-279 (1998).
- Papke, R. L., and J. S. Thinschmidt. The Correction of Alpha7 Nicotinic Acetylcholine Receptor Concentration-Response Relationships in Xenopus Oocytes. Neuroscience Letters 256:163-166 (1998).
- Meyer, E., A. Kuryatov, V. Gerzanich, J. Lindstrom, and R. L. Papke. Analysis of 40H-GTS-21 Selectivity and Activity at Human and Rat alpha 7 Nicotinic Receptors. Journal of Pharmacology and Experimental Therapeutics 287(3):918-25 (1998).
- Li, Y., R. L. Papke, Y.-J. He, B. Millard, and E. M. Meyer. Characterization of the neuroprotective and toxic effects of alpha 7 nicotinic receptor activation in PC12 cells. Brain Research 81(4):218-25 (1999).
- Karkanias, N., and R. Papke. Subtype-specific effects of lithium on glutamate receptor function. 81(4):1506-12 (1999).
- Webster, J. C., M. M. Francis, J. K. Porter, G. Robinson, C. Stokes, B. Horenstein, and R. L. Papke. Antagonist activities of mecamylamine and nicotine show reciprocal dependence on beta subunit sequence in the second transmembrane domain. British Journal of Pharmacology 127:1337-48 (1999).
- Karkanias, N. B., and R. L. Papke. Lithium modulates desensitization of the glutamate receptor subtype gluR3 in Xenopus oocytes. Neuroscience Letters 277(3):153-6 (1999).
- Papke, R. L., E. Meyer, T. Nutter, and V. V. Uteshev. Alpha7-selective agonists and modes of alpha7 receptor activation. European Journal of Pharmacology 393((1-3)):179-95 (2000).
- Papke, R. L., J. C. Webster, P. M. Lippiello, M. Bencherif, and M. M. Francis. The activation and inhibition of human nAChR by RJR-2403 indicate a selectivity for the a4b2 receptor subtype. Journal of Neurochemistry 75:204-216 (2000).
- Francis, M. M., R. W. Vazquez, R. L. Papke, and R. E. Oswald. Subtype-selective inhibition of neuronal nicotinic acetylcholine receptors by cocaine is determined by the alpha4 and beta4 subunits. Molecular Pharmacology 58(1):109-19 (2000).
- Roger L. Papke, Paul R. Sanberg, R. Douglas Shytle, 2001. Analysis of Mecamylamine Stereoisomers on Human Nicotinic Receptor Subtypes. Journal of Pharmacology and Experimental Therapeutics, 297:646656,.
- Roger L. Papke, Benjamin A. Horenstein, and Andon N. Placzek. Inhibition of Wild-Type and Mutant Neuronal Nicotinic Acetylcholine Receptors by Local Anesthetics. Molecular Pharmacology. 60:13651374, 2001.
- Simon M. N. Efange, Zhude Tu, Krystyna von Hohenberg, Lynn Francesconi, Robertha C. Howell, Marilyn V. Rampersad, Louis J. Todaro, Roger L. Papke, and Mei-Ping Kung. 2-(2-Piperidyl)- and 2-(2-Pyrrolidyl) chromans as Nicotine Agonists: Synthesis and Preliminary Pharmacological Characterization. J. Med. Chem. 44:4704-4715, 2001.
- A.Y. Kabakov, Ph.D. and R.L. Papke, Ph.D. Ultra Fast Solution Applications for Prolonged Gap-free Recordings: Controlling a Burleigh Piezo-Electric Positioner with Clampex 7.
- Roger L. Papke 2002. Enhanced inhibition of a mutant neuronal nAChR by
agonists: protection of function by TC-2403. Journal of Pharmacology and
Experimental Therapeutics.301:765-773, 2002.
- Roger L. Papke and Julia K. Porter Papke. Comparative pharmacology of rat and human alpha7 nAChR conducted with net charge analysis. British Journal of Pharmacology,137:49-61, 2002.
- Vladimir V. Uteshev, Edwin M. Meyer, and Roger L. Papke. Activation and inhibition of native neuronal alpha-bungarotoxin-sensitive nicotinic ACh receptors. Brain Research, 948: 33-46, 2002.
- The Use of Net Charge Analysis in the Study of Ion Channel Pharmacology. Axobits, 6-9, 2002.
- The Use of Net Charge Analysis in the Study of Ion Channel Pharmacology- long version.
- Vladimir V. Uteshev, Edwin M. Meyer, and Roger L. Papke. Regulation of neuronal function by choline and 4OH-GTS-21 through alpha7 nicotinic receptors J. Neurophysiol, 89: 1797-1806, 2003
- Daisuke Takedaa, Terumasa Nakatsukaa, Roger Papke, Jianguo G. Gu. Modulation of inhibitory synaptic activity by a non-alpha4beta2, non-alpha7 subtype of nicotinic receptors in the substantia gelatinosa of adult rat spinal cord. Pain, 101: 13-23, 2003.
- Charles J. Frazier, Ben W. Strowbridge, and Roger L. Papke. Nicotinic acetylcholine receptors on local circuit neurons in the dentate gyrus: a potential role in the regulation of granule cell excitability. J Neurophysiol, 89: 3018-3028, 2003.
- William R. Kem, Vladimir M. Mahnir,1 Laszlo Prokai, Roger L. Papke, Xuefang Cao,
Susan LeFrancois, Kristin Wildeboer, Katalin Prokai-Tatrai, Julia Porter-Papke, and Ferenc Soti. Hydroxy Metabolites of the Alzheimer’s Drug Candidate 3-
[(2,4-Dimethoxy)Benzylidene]-Anabaseine Dihydrochloride (GTS-21): Their Molecular Properties, Interactions with Brain Nicotinic Receptors, and Brain Penetration. Mol Pharmacol,65: 56-67, 2004
- Mario B. Marrero, Roger L. Papke, Balwinder S. Bhatti, Seán Shaw,
and Merouane Bencherif. THE NEUROPROTECTIVE EFFECT OF TC-1698, A NOVEL ALPHA7 LIGAND, IS
PREVENTED THROUGH ANGIOTENSIN II ACTIVATION OF A TYROSINE
PHOSPHATASE. JPET ,309: 16-27 2003
- Roger L. Papke, Edwin M. Meyer, Sophie Lavieri, Sirisha R. Bollampally, Thaddeus Papke, Nicole A. Horenstein, Yoshitsugu Itoh, and Julia K. Porter Papke. Effects at a distance in alpha7 nAChR selective agonists: Benzylidene substitutions that regulate potency and efficacy. Journal of Neuropharmacology ,46: 1023-1038 2004
- Roger L. Papke, Julia K. Porter-Papke, and G.M. Rose. Activity of alpha7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes. in press - Bioorganic & Medicinal Chemistry Letters, 9/17/2003
- Clare Stokes, Julia Kay Porter Papke, Nicole A. Horenstein, William R. Kem, Thomas J. McCormack and Roger L. Papke. The structural basis for GTS-21 selectivity between human and rat nicotinic alpha7 receptors. Molecular Pharmacology, 66: 14-24, 2004
- John Dominy, Jr., Jeffrey S. Thinschmidt, Joanna Peris, Ralph Dawson, Jr., and
Roger L. Papke. Taurine-induced long-lasting potentiation in the rat hippocampus shows a partial dissociation from total hippocampal taurine content and independence from activation of known taurine transportersJournal of Neurochemistry, 89: 1195-1205 2004
- Andon N. Placzek, Francesca Grassi, Thaddeus Papke, Edwin M. Meyer, and Roger L. Papke. 2004. A single point mutation confers properties of the muscle-type nicotinic acetylcholine receptor to homomeric alpha7 receptors. Molecular Pharmacology, 66: 169-177, 2004
- Roger L. Papke, Hillary C. Schiff, Brian A. Jack, Nicole A. Horenstein. 2005. Molecular dissection of tropisetron, an alpha7 nicotinic acetylcholine receptor-selective partial agonist. Neuroscience Letters, 378:140-144 2005
- Roger L. Papke, Joshua D. Buhr, Michael M. Francis, Kyung Il Choi, Jeffrey S. Thinschmidt, and Nicole A. Horenstein. The effects of subunit composition on the inhibition of nicotinic receptors by the amphipathic blocker TMPH. Molecular Pharmacology, 67: 1977-90 2005
- Jeffrey S. Thinchmidt, Charles J. Frazier, Michael A. King, Edwin M. Meyer, and Roger L. Papke. Septal innervation regulates the function of alpha7 nicotinic receptors in Ca1 hippocampal interneurons.Experimental Neurology, 195:342-352 2005
- John H. Graham, Roger L. Papke, Jerry J. Buccafusco. Functional Central Nicotinic Acetylcholine Receptor Antagonism by Systemic Administration of Tinuvin 770 (BTMPS). Current Alzheimers Research, 2:141-147, 2005
- Ke Ren, Viviana Puig, Roger L. Papke, Yoshihito Itoh, Jeffrey A. Hughes, and Edwin M. Meyer. Multiple calcium channels and kinases mediate alpha7 nicotinic receptor neuroprotection in PC12 cells. Journal of Neurochemistry, 94:926-33 2005
- Roger L. Papke, Guangrong Zheng, Nicole A. Horenstein, Linda P. Dwoskin, and Peter A. Crooks. The characterization of a novel rigid nicotine analog with alpha7-selective nAChR agonist activity and modulation of agonist properties by boron inclusion. Bioorganic & Medicinal Chemistry Letters, 15:3874-3880 2005
- Jeffrey S. Thinschmidt, Charles J. Frazier, Michael A. King, Edwin M. Meyer, and Roger L. Papke. Medial septal/diagonal band cells express multiple functional nicotinic receptor sub-types that are correlated with firing frequency.Neuroscience letters, 389:163-168 2005
- M. Imad Damaj, Jenny L. Wiley, Billy R. Martin, and Roger L. Papke. In vivo characterization of a novel inhibitor of CNS nicotinic receptors. European Journal of Pharmacology521: 43-48, 2005
- Roger L. Papke, Thomas J. McCormack, Brian A. Jack, Daguang Wang, Bozena Bugaj-Gaweda, Hillary C. Schiff, Joshua D. Buhr, Amanda J. Waber, and Clare Stokes. Rhesus monkey alpha7 nicotinic acetylcholine receptors: comparisons to human alpha7 receptors expressed in Xenopus oocytes.European Journal of Pharmacology524: 11-18, 2005
- Andon N. Placzek, Francesca Grassi, Edwin M. Meyer, and Roger L. Papke. 2005. An alpha7 nicotinic acetylcholine receptor
gain-of-function mutant that retains pharmacological fidelity.Molecular Pharmacology68: 1863-76, 2005
- Roger L. Papke 2006. Estimation of both the potency and efficacy of alpha7 nAChR agonists from single concentration responses.Life Sciences78: 2812-19, 2006
- Roger L. Papke, Linda P. Dwoskin and Peter A. Crooks 2006. The pharmacological activity of nicotine and nornicotine on nAChRs subtypes, Relevance to nicotine dependence and drug discovery.Journal of Neurochemistry101: 160-7
- Ke Ren, Jeffrey S.Thinschmidt, Ai Lin, Roger L. Papke, Michael A. King, Edwin M. Meyer 2007. Alpha7 nicotinic receptor gene delivery into mouse hippocampal neurons leads to functional receptor expression, improved spatial memory-related performance, and tau hyperphosphorylation.Neuroscience 145: 314-22
- Nicole A. Horenstein, Thomas J. McCormack, Clare Stokes, Ke Ren, and Roger L. Papke 2006. Reversal of Agonist Selectivity by Mutations of Conserved Amino Acids in the Binding Site of Nicotinic Acetylcholine Receptors.Journal of Biological Chemistry 282: 5899-909
- Fedra M. Leonik, Roger L. Papke, Nicole A. Horenstein. 2007. Quinuclidines as selective agonists for alpha-7 nicotinic acetylcholine receptors.Bioorganic & Medicinal Chemistry Letters: 17: 1520-22
- Gretchen Lopez-Hernandez, Andon N. Placzek, Jeffery S. Thinschmidt, Pierre Lestage, Caryn Trocme-Thibierge, Philippe Morain, and Roger L. Papke 2007. Partial agonist and neuromodulatory activity of S 24795 for alpha7 nAChR responses of hippocampal interneurons.Neuropharmacology 53: 134-44
- Linda P. Dwoskin, Barry M. Joyce, Guangrong Zheng, Nichole M. Neugebauer, Vamshi K. Manda, Paul Lockman, Roger L. Papke, Michael T. Bardo, and Peter A. Crooks. 2007. Discovery of a novel nicotinic receptor antagonist for the treatment of nicotine addiction: TMPD.Biochemical Pharmacology 74: 1271-82
- Shafiqur Rahman1, Zhenfa Zhang, Roger L. Papke, Peter A. Crooks, Linda P. Dwoskin, and
Michael T. Bardo. 2008. Region-specific effects of bPiDDB on in vivo nicotine-induced increase in extracellular dopamine.British Journal of Pharmacology153(4):792-804
- Roger L. Papke and Cathy Smith-Maxwell. 2008. High-throughput electrophysiology with Xenopus oocytes.Combinatorial Chemistry and High Throughput Screening in Press
- Jeffrey S. Thinschmidt, Ke Ren, Michael A. King, Edwin M. Meyer, and Roger L. Papke. 2008. Modulation of spontaneous hippocampal synaptic events with 5-hydroxyindole, 4OH GTS-21, and rAAV- mediated alpha7 nicotinic receptor gene transfer.Brain Research1203:51-60.
- Roger L. Papke, Linda P. Dwoskin, Peter A. Crooks, Guangrong Zheng, Zhenfa Zhang, J. Michael McIntosh and Clare Stokes. 2008. Extending the analysis of nicotinic receptor antagonists with the study of alpha6 nicotinic receptor subunit chimeras. Neuropharmacology54(8)
1189-200
- Fiana Levitin, Mordechai Weiss, Yoonsoo Hahn, Omer Stern, Roger L. Papke, Robert Matusik, Srinivas R. Nandana, Ravit Ziv, Edward Pichinuk, Sharbel Salame, Tapan Bera, James Vincent, Byungkook Lee, Ira Pastan, and Daniel H. Wreschner. 2008. Gene Clusters Code for Multiple, Secreted, TFP/Ly-6/uPAR Proteins That Are Expressed in Reproductive and Neural-Rich Tissues and Possess Neuromodulatory Activity.Journal of Biological Chemistry283(24)
16928-39
- Nicole A. Horenstein, Fedra M. Leonik, and Roger L. Papke. 2008. Multiple pharmacophores for the selective activation of nicotinic alpha7-type acetylcholine receptors.Molecular Pharmacology741496-1511
- Xiaoqin Huang, Fang Zheng, Clare Stokes, Roger L. Papke, and Chang-Guo Zhan. 2008. Modeling binding modes of alpha7 nicotinic acetylcholine receptor with ligands: the roles of Gln117 and other residues of the receptor in agonist binding.Journal of Medicinal Chemistryin Press
- Jingyi Wang, Roger L. Papke, and Nicole A. Horenstein 2008. Synthesis of H-bonding probes of alpha7 nAChR agonist selectivity.Bioorganic and Medicinal Chemistry Lettersin Press
